Figure 5.

A Combination of AA and NG Effectively Rebalances TGF-β1/Smad Signaling in Tumor-Infiltrating NK Cells by Additively Repressing Smad3 Phosphorylation while Enhancing Smad7 Expression

(A and B) Two-color immunofluorescence detecting NK1.1⁺p-Smad3⁺ (A) and NK1.1⁺Smad7⁺ (B) NK cells in the LLC tumor microenvironment. NK1.1, green; p-Smad3 or Smad7, red; DAPI, blue. Each bar represents the mean ± SEM for groups of three to four mice; *p < 0.05, **p < 0.01, and ***p < 0.001 compared to control; ##p < 0.01 and ###p < 0.001 as indicated. Scale bar, 100 μm.