Figure 6.

Retrieving the Balance of Smad3/Smad7 Signaling with AA and NG Attenuates TGF-β1-Induced Inhibition on NK Cell Differentiation

(A) Flow cytometry shows the inhibitory effect of TGF-β1 on NK cell differentiation as determined by NK1.1⁺ CD122⁺ population in bone marrow-derived NK cells (day 9). ***p < 0.001 compared to control; #p < 0.05 as indicated. (B) Flow cytometry detects the effects of AA, NG, and their combination on bone marrow-derived NK differentiation in response to TGF-β1 (5 ng/mL). Each bar represents the mean ± SEM for groups of three independent experiments; ***p < 0.001 compared to TGF-β1; ###p < 0.001 as indicated.