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. 2018 Sep 6;11:500. doi: 10.1186/s13071-018-3072-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Plasma levels of specific rFhCL1 IgG1 (a) and IgG2 (b). Each point represents mean values of antibody titre - log10 - (IgG1) and of optical density (IgG2) measured at 450 nm. Bars at each point represents tandard error. Immunisation with rFhCL1 developed a significant rise in the level of IgG1 isotype; dynamics of IgG1 in uninfected and infected sheep (Groups 1 and 2) shows a similar pattern, hence it is overlapped in the figure. Significant IgG2 production was detected only at 1 day post-infection (dpi) during the trial