Table 6.
The risk estimation of analysed variables and clinical status for exclusively haematogenous versus lymphogenous dissemination in breast cancer patients (logistic regression adjusted for age)
| Variables | P value | OR | 95% CI | |
|---|---|---|---|---|
| CTC + LNM- vs. CTC-LNM+ | ↑ Methylation of ADAM23 in PT | 0.023 | 0.45 | 0.229–0.898 |
| ↑ Methylation of CXCL12 in PBCs | 0.046 | 0.07 | 0.005–0.949 | |
| ↑ Methylation of TWIST1 in PBCs | 0.050 | 0.03 | 0.001–0.998 | |
| Tumour size > 20 mm | 0.055 | 0.04 | 0.001–1.073 |
−2 Log likelihood = 15.22; R2(Cox and Snell) = 0.57; R2(Nagelkerke) = 0.81
Abbreviations: LNM lymph node metastases, CTC circulating tumour cells, OR odds ratio, CI confidence interval, ↑ continuous variable. Age and DNA methylation of genes significant in univariate analysis, hormone receptor and HER2 status, histological type, tumour size and Ki-67 proliferative index were analysed as independent variables, significant or borderline significant results are shown in the table