Fig. 1.

The three included relationship scenarios. The three scenarios of relationships between drug targets and disease proteins are shown along with examples which can be found in the knowledge graph. a Drug target (DT) and disease protein (DP) are the same protein. The protein may have a relationship with itself (dotted line). b DT and DP have a direct relationship. c DT and DP have an indirect relationship through an intermediate protein (IP). Indirect relationships consist of two steps (DTIP and IPDP)