Table 3.

Main and sensitivity analyses of predictors of relapse for patients discharged from early intervention in psychosis services

	Main analysisa			In-patient at discharge excludedb			Schizophrenia as separate diagnostic categoryc			Readmission to hospitald
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Diagnosis
Schizophrenia							1 (reference)
Non-affective psychosis	1 (reference)			1 (reference)			0.37	0.18–0.75	0.006	1 (reference)
Affective psychosis	1.63	0.92–2.87	0.091	1.50	0.81–2.78	0.197	1.22	0.67–2.20	0.520	1.58	0.84–2.96	0.158
Mood and anxiety disorders	1.68	0.45–2.97	0.076	1.65	0.92–2.95	0.092	1.05	0.55–1.98	0.888	1.43	0.73–2.75	0.310
Personality disorders	2.96	1.39–6.29	0.005	2.99	1.35–6.62	0.007	2.43	1.16–5.11	0.019	2.43	1.01–5.83	0.047
Other	0.77	0.21–2.78	0.689	0.59	0.13–2.74	0.503	0.58	0.17–2.02	0.391	1.09	0.29–4.08	0.892
Number of admissions	1.17	0.96–1.43	0.116	1.18	0.94–1.47	0.149	1.16	0.96–1.41	0.131	1.27	1.03–1.57	0.026
Early intervention duration, months	1.02	1.01–1.04	0.001	1.02	1.01–1.04	0.002	1.01	1.00–1.03	0.023	1.02	1.01–1.04	0.009
Discharge destination, secondary care	2.75	1.75–4.31	0.001	2.80	1.75–4.51	0.001	2.40	1.52–3.79	0.001	2.52	1.49–4.23	0.001
Age at referral	1.03	0.99–1.07	0.225	1.03	0.99–1.08	0.117	1.03	0.99–1.07	0.218	1.04	0.99–1.09	0.093
Gender, female	1.40	0.92–2.14	0.114	1.43	0.92–2.22	0.108	1.33	0.88–2.13	0.180	1.51	0.93–2.45	0.097
Ethnicity
White	1 (reference)			1 (reference)			1 (reference)			1 (reference)
Black	0.92	0.39–2.17	0.844	0.98	0.41–2.36	0.964	0.88	0.36–2.13	0.776	0.81	0.29–2.25	0.692
Asian	0.43	0.18–1.03	0.057	0.45	0.19–1.11	0.082	0.38	0.16–0.91	0.030	0.58	0.23–1.43	0.234
Other	0.98	0.46–2.09	0.966	0.96	0.43–2.15	0.918	0.91	0.43–1.92	0.801	1.27	0.56–2.87	0.571
IMD score	1.03	1.01–1.05	0.002	1.04	1.02–1.06	0.001	1.03	1.01–1.05	0.003	1.04	1.02–1.07	0.001
Substance misuse disorder	1.81	1.01–3.26	0.048	1.86	0.99–3.48	0.052	1.77	0.99–3.16	0.052	1.75	0.90–3.38	0.099

IMD, Index of Multiple Deprivation.

a. Primary analysis including all participants.

b. Sensitivity analysis excluding those discharged by early intervention in psychosis services while psychiatric in-patient.

c. Sensitivity analysis with schizophrenia as a separate diagnostic category.

d. Sensitivity analysis with relapse defined as readmission to psychiatric in-patient hospital.