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. 2018 Oct;13(10):1715–1718. doi: 10.4103/1673-5374.238607

Figure 2.

Figure 2

Remodelling of the cholinergic transmission gene networks.

In the set of experiments with treatments, the betamethasone-primed (B) rats after the first trigger of spasms (Y) were randomized into treatment groups treated either with full molecule of rat ACTH (BYA group), PMX53 (BYP group) or Saline (BYS group). (A) Part of the pathway regulated by the activation of the cholinergic receptors of the presynaptic and postsynaptic neurons. M2/4: Muscarinic metabotropic acetylcholine receptors (Chrm2/4); Gi/o: G-proteins (Gnai1/2/3, Gnao1, Gnb1/2/3/4/5, Gng10/11/12/13/3/5/7/8); VCCC: voltage-dependent calcium channels (Cacna1a/b); AC: adenylate cyclases (Adcy2/3/4/5/7/8/9). (B–E) Gene expression correlation in the SNS (the absolute control: not betamethasone-primed no spasms pups treated with saline), BNS, BYS, BYA and BYP conditions.