Table 1.
Baseline and treatment characteristics stratified by achievement of benchmarked dosimetric criteria (mean lung dose ≤13.5 Gy and percent of lung volume receiving less than 5 Gy ≤55%)
| Characteristic | Total | Yes | % | No | % | P-value |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Female | 108 | 78 | 54.2 | 30 | 65.2 | .188 |
| Male | 82 | 66 | 45.8 | 16 | 34.8 | |
| Ethnicity | ||||||
| White | 137 | 105 | 72.9 | 32 | 69.6 | .958 |
| African-American | 14 | 10 | 6.9 | 4 | 8.7 | |
| Hispanic | 26 | 19 | 13.2 | 7 | 15.2 | |
| Other | 13 | 10 | 6.9 | 3 | 6.5 | |
| Tumor histology | ||||||
| Non-Hodgkin lymphoma | 56 | 41 | 28.5 | 15 | 32.6 | .592 |
| Hodgkin lymphoma | 134 | 103 | 71.5 | 31 | 67.4 | |
| Disease stage | ||||||
| I | 19 | 17 | 11.8 | 2 | 4.4 | .447 |
| II | 138 | 104 | 72.2 | 34 | 73.9 | |
| III | 14 | 10 | 6.9 | 4 | 8.7 | |
| IV | 19 | 13 | 9.0 | 6 | 13.0 | |
| Asthma/COPD | ||||||
| No | 175 | 131 | 91.0 | 44 | 95.7 | .306 |
| Yes | 15 | 13 | 9.0 | 2 | 4.4 | |
| ABVD | ||||||
| No | 68 | 49 | 34.0 | 19 | 41.3 | .370 |
| Yes | 122 | 95 | 66.0 | 27 | 58.7 | |
| Smoking history | ||||||
| No | 151 | 114 | 79.2 | 37 | 80.4 | .853 |
| Yes | 39 | 30 | 20.8 | 9 | 19.6 | |
| Bulky disease (>10 cm) | ||||||
| No | 75 | 63 | 43.8 | 12 | 26.1 | .033 |
| Yes | 115 | 81 | 56.3 | 34 | 73.9 | |
| Required salvage chemotherapy | ||||||
| No | 146 | 119 | 82.6 | 27 | 58.7 | .001 |
| Yes | 44 | 25 | 17.4 | 19 | 41.3 | |
| Bleomycin toxicity | ||||||
| No | 156 | 118 | 81.9 | 38 | 82.6 | .919 |
| Yes | 34 | 26 | 18.1 | 8 | 17.4 | |
| Deep-inspiration breath-hold | ||||||
| No | 80 | 50 | 34.7 | 30 | 65.2 | < .001 |
| Yes | 110 | 94 | 65.3 | 16 | 34.8 | |
| History of stem cell transplant | ||||||
| Yes | 43 | 24 | 16.7 | 19 | 41.3 | .001 |
| No | 147 | 120 | 83.3 | 27 | 58.7 | |
| Brentuximab | ||||||
| No | 170 | 133 | 92.4 | 37 | 80.4 | .022 |
| Yes | 20 | 11 | 7.6 | 9 | 19.6 |
ABVD, adriamycin, bleomycin, vinblastine, and dacarbazine; COPD, chronic obstructive pulmonary disease.