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. 2018 Sep 7;2(9):1080–1094. doi: 10.1002/hep4.1225

Figure 6.

Figure 6

Depletion of Kupffer cells with clodronate liposomes induces an increase in serum CD26/DPP‐4 enzymatic levels. (A) Groups of three C57BL/6 males were injected with liposomes containing clodronate (5 g/mL) or PBS and analyzed at 2, 7, 14, and 30 days postinjection. The proportion of LY6C+ monocyte/macrophage cells in the liver at (B) day 2, (C) day 7, and (D) day 14 is represented. (E,F) The proportion of Kupffer cells is superimposed on the levels of serum CD26/DPP‐4 activity measured in treated mice and compared to untreated control mice at the same time points. Arbitrary units represent the rate of substrate decay during the enzymatic assay normalized to the average value of the controls. Scale bar, 100 μm. Mean values and error bars indicating SD are represented. *P <0.05, **P <0.01, and ***P <0.001 in one‐way analysis of variance using Tukey's multiple comparison test. Data are representative of two independent experiments, n = 3‐4 mice/group. Abbreviations: A.U., arbitrary units; i.v., intravenous.