Table 2.
Characteristics of Preeclamptic Births in EMC Case-Only Study, by Fetal APOL1 Genotype
| Fetal APOL1 Genotype | All (n = 121) | APOL1 LR (n = 97) | APOL1 HR (n = 24) | p Value |
|---|---|---|---|---|
| Maternal Risk Factors for Preeclampsia | ||||
| Maternal age, year (IQR) | 29.0 (11.0) | 28.0 (10.0) | 31.5 (8.5) | 0.09 |
| Nulliparity, n (%) | 25 (21%) | 21 (22%) | 4 (17%) | 0.78 |
| Obesity, n (%) | 30 (25%) | 26 (27%) | 4 (17%) | 0.43 |
| History of hypertension, n (%) | 34 (28%) | 27 (28%) | 7 (29%) | 1.00 |
| History of diabetes, n (%) | 11 (9%) | 9 (9%) | 2 (8%) | 1.00 |
| History of prior preeclampsia, n (%) | 22 (18%) | 17 (18%) | 5 (21%) | 0.77 |
| History of spontaneous abortion, n (%) | 23 (19%) | 16 (16%) | 7 (29%) | 0.16 |
| Perinatal Outcomes | ||||
| Early-onset preeclampsia, n (%) | 56 (46%) | 43 (44%) | 13 (54%) | 0.50 |
| Cesarean delivery, n (%) | 78 (64%) | 62 (64%) | 16 (67%) | 1.00 |
| Gestational age, weeks (IQR) | 35.4 (5.6) | 35.7 (5.0) | 34.4 (6.2) | 0.29 |
| Birth weight, g (IQR) | 2,360 (1,335) | 2,415 (1,280) | 2,193 (1,064) | 0.35 |
| Apgar score, 1 min (IQR) | 8.0 (3.0) | 8.0 (3.0) | 7.0 (5.0) | 0.07 |
| Apgar score, 5 min (IQR) | 9.0 (1.0) | 9.0 (1.0) | 8.0 (1.0) | 0.01a |
RA refers to APOL1 risk allele, either G1 (p.Ser342Gly mutation) or G2 (a 6 bp deletion p.Asn388_Tyr389del). The HR genotype consists of 2 RA. The LR genotype consists of 0 or 1 RA. Continuous variables are reported as median and interquartile range in parentheses. The high-risk APOL1 genotype group was compared to the low-risk APOL1 genotype group using the Wilcoxon rank sum test with continuity correction continuous variables and a two-tailed Fisher exact test for categorical variables.
a
p value ≤ 0.05