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(A–D). After 24 h cultivation, GDF11 showed no effect on total protein of Smad2/3, Creb, p38 and Erk, but significantly phosphorylated Smad2 (Ser465/467), Smad3(Ser423/425), Creb(Ser133), p38(Thr180/Tyr182) and Erk (Thr202/Tyr204) in C17.2 cells. N = 4, *p < 0.05, **p < 0.01 and ***p < 0.001 when compared with control.
