Table 1.
Association between SRPK1 expression and clinicopathological parameters in CRC patients
| Clinicopathological parameters | Case number | SRPK1, n (%)
|
P-value | |
|---|---|---|---|---|
| Low | High | |||
| Total | 85 | 41 (48.24) | 44 (51.76) | |
| Gender | 0.562 | |||
| Male | 47 | 24 (51.06) | 23 (48.94) | |
| Female | 38 | 17 (44.74) | 21 (55.26) | |
| Age, years | 0.406 | |||
| <60 | 35 | 15 (42.86) | 20 (57.14) | |
| ≥60 | 50 | 26 (52.00) | 24 (48.00) | |
| Location | 0.724 | |||
| Colon | 39 | 18 (46.15) | 21 (53.85) | |
| Rectum | 46 | 23 (50.00) | 23 (50.00) | |
| Tumor size, cm | 0.299 | |||
| <5 | 49 | 26 (53.06) | 23 (46.94) | |
| ≥5 | 36 | 15 (41.67) | 21 (58.33) | |
| TNM stage | 0.001* | |||
| I + II | 42 | 28 (66.67) | 14 (33.33) | |
| III + IV | 43 | 13 (30.23) | 30 (69.77) | |
| Differentiation | 0.544 | |||
| Well/moderately | 66 | 33 (50.00) | 33 (50.00) | |
| Poorly | 19 | 8 (42.11) | 11 (57.89) | |
| T stage | 0.030* | |||
| T1 + T2 | 22 | 15 (68.18) | 7 (31.82) | |
| T3 + T4 | 63 | 26 (41.27) | 37 (58.73) | |
| N stage | 0.000** | |||
| N0 | 52 | 33 (63.46) | 19 (36.54) | |
| N1 + N2 | 33 | 8 (24.24) | 25 (75.76) | |
| M stage | 0.108* | |||
| M0 | 79 | 40 (50.63) | 39 (49.37) | |
| M1 | 6 | 1 (16.67) | 5 (83.33) | |
Note:
*
P<0.05,
**
P<0.001.
Abbreviations: CRC, colorectal cancer; SRPK1, serine/arginine protein kinase 1; TNM, tumor node metastasis.