Table 2.
Univariate and multivariate analyses of various prognostic parameters in patients with CRC Cox regression analysis
| Variable | Univariate analysis
|
Multivariate analysis
|
|||
|---|---|---|---|---|---|
| OS months (mean ± SD) | P-value | HR | P-value | 95% CI | |
| Gender | 0.111 | ||||
| Male | 50.155±2.589 | ||||
| Female | 58.145±2.901 | ||||
| Age, years | 0.515 | ||||
| <60 | 51.270±4.648 | ||||
| ≥60 | 56.730±3.099 | ||||
| Location | 0.882 | ||||
| Colon | 56.830±1.036 | ||||
| Rectum | 51.270±5.251 | ||||
| Tumor size, cm | 0.983 | ||||
| <5 | 56.730±0.826 | ||||
| ≥5 | 51.270±6.930 | ||||
| TNM stage | <0.000** | ||||
| I + II | 66.571±1.492 | Reference | |||
| III + IV | 42.189±2.669 | 2.984 | 0.011* | 1.288–6.912 | |
| T stage | 0.027* | ||||
| T1, T2 | 64.946±1.981 | ||||
| T3, T4 | 48.965±2.271 | ||||
| N stage | <0.000** | ||||
| N0 | 64.107±1.556 | Reference | |||
| N1 + N2 | 38.586±3.037 | 2.059 | 0.062 | 0.965–4.394 | |
| M stage | <0.000** | ||||
| M0 | 57.126±1.835 | ||||
| M1 | 20.302±7.558 | ||||
| Differentiation | 0.323 | ||||
| Well/moderately | 57.005±2.031 | ||||
| Poorly | 44.402±5.075 | ||||
| SRPK1 expression | 0.001* | ||||
| Low | 62.248±1.788 | Reference | |||
| High | 45.101±2.901 | 1.914 | 0.031* | 1.061–3.453 | |
Note:
*
P<0.05,
**
P<0.001.
Abbreviations: CRC, colorectal cancer; OS, overall survival; SRPK1, serine/arginine protein kinase 1; TNM, tumor node metastasis.