Table 3.
Serotype distribution among IPD and AE-COPD in COPD patients
| IPD
|
AE-COPD
|
OR | 95% CI | |||
|---|---|---|---|---|---|---|
| Number of isolates | % | Number of isolates | % | |||
| Total | 57 | 16.5 | 210 | 60.9 | ||
| Serotype | ||||||
| PCV7 | 3 | 5.26 | 16 | 7.6 | 0.67 | (0.19–2.39) |
| 4 | 0 | 0 | 0 | 0 | − | (−/−) |
| 6B | 0 | 0 | 1 | 0.5 | 0.00 | (0/−) |
| 9V | 0 | 0 | 1 | 0.5 | 0.00 | (0/−) |
| 14 | 2 | 3.51 | 0 | 0 | ∞ | (−/∞) |
| 18C | 0 | 0 | 2 | 1 | 0.00 | (0/−) |
| 19F | 1 | 1.75 | 11 | 5.2 | 0.32 | (0.04–2.55) |
| 23F | 0 | 0 | 1 | 0.5 | 0.00 | (0/−) |
| PCV13 | 18 | 31.6 | 35 | 17 | 2.31 | (1.18–4.49) |
| Additional PCV13 | 15 | 26.3 | 19 | 9 | 6.50 | (3.03–13.91) |
| 1 | 1 | 1.75 | 0 | 0 | 0.00 | (0/−) |
| 3 | 8 | 14.0a | 5 | 2.4 | 6.69 | (2.10–21.35 |
| 5 | 0 | 0 | 0 | 0 | − | (−/−) |
| 6A | 0 | 0 | 0 | 0 | − | (−/−) |
| 7F | 3 | 5.26 | 1 | 0.5 | 11.61 | (1.18–113.84) |
| 19A | 3 | 5.26 | 13 | 6.2 | 0.84 | (0.23–3.06) |
| Non-PCV13 | 39 | 68.4 | 175 | 83 | 0.43 | (0.22–0.84) |
| 6C | 3 | 5.26 | 21 | 10 | 0.50 | (0.14–1.74) |
| 8 | 8 | 14.0a | 2 | 1 | 16.98 | (3.5–82.47) |
| 9N/L | 3 | 5.26 | 5 | 2.4 | 2.28 | (0.53–9.83) |
| 10A | 2 | 3.51 | 8 | 3.8 | 0.92 | (0.19–4.45) |
| 11A | 3 | 5.26 | 23 | 11 | 0.45 | (0.13–1.56) |
| 12F | 5 | 8.8a | 0 | 0 | ∞ | (−/∞) |
| 16F | 0 | 0 | 7 | 3.3 | 0.00 | (0/−) |
| 17F | 2 | 3.51 | 2 | 1 | 3.80 | (0.52–27.45) |
| 22F | 2 | 3.51 | 6 | 2.9 | 1.23 | (0.24–6.29) |
| 23A | 3 | 5.26 | 10 | 4.8 | 1.11 | (0.29–4.17) |
| 23B | 3 | 5.26 | 8 | 3.8 | 1.40 | (0.36–5.46) |
| 24F | 0 | 0 | 8 | 3.8 | 0.00 | (0/−) |
| 31 | 3 | 5.26 | 13 | 6.2 | 0.84 | (0.23–3.06) |
| 35B | 2 | 3.51 | 8 | 3.8 | 0.91 | (0.18–4.44) |
| Others | 0 | 0 | 54 | 26 | 0.00 | (0/−) |
Note:
a
Serotypes whose frequency is significantly higher among IPD than that among AE-COPD.
Abbreviations: AE-COPD, acute exacerbation of COPD; COPD, chronic obstructive pulmonary disease; IPD, invasive pneumococcal disease; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine.