Table S3.
Changes in the clonal composition of pneumococci causing AE-COPD
| Clonal complex | Number of isolates | Serotype related (number of isolates) | 2001–20041
|
2005–20081
|
2009–20121
|
2013–2016
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| 136 | (%) | 211 | (%) | 198 | (%) | 210 | (%) | |||
| 156 | 54 | 9V (16) | 10 | 7.4 | 4 | 1.9 | 1 | 0.5 | 0 | 0.0 |
| 14 (16) | 7 | 5.1 | 7 | 3.3 | 2 | 1.0 | 1 | 0.5 | ||
| 11A (22) | 0 | 0.0 | 0 | 0.0 | 3 | 1.5 | 19 | 9.0 | ||
| 63 | 35 | 15A (30) | 3 | 2.2 | 6 | 2.8 | 17 | 8.6 | 4 | 1.9 |
| 19F (4) | 2 | 1.5 | 1 | 0.5 | 1 | 0.5 | 0 | 0.0 | ||
| 15F (1) | 1 | 0.7 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
| 62 | 31 | 11A (31) | 9 | 6.6 | 10 | 4.7 | 8 | 4.0 | 4 | 1.9 |
| 180 | 28 | 3 (28) | 7 | 5.1 | 9 | 4.3 | 9 | 4.5 | 3 | 1.4 |
| 30 | 27 | 16F (27) | 6 | 4.4 | 8 | 3.8 | 7 | 3.5 | 6 | 2.9 |
| 42 | 27 | 23A (25) | 4 | 2.9 | 10 | 4.7 | 5 | 2.5 | 7 | 3.3 |
| 19A (1) | 0 | 0.0 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | ||
| 23F (1) | 0 | 0.0 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | ||
| 386 | 25 | 6C (24), 6A (1) | 0 | 0.0 | 0 | 0.0 | 7 | 3.5 | 18 | 8.6 |
| 81 | 22 | 23F (12) | 7 | 5.1 | 5 | 2.3 | 0 | 0.0 | 0 | 0.0 |
| 19A (6) | 3 | 2.2 | 1 | 0.5 | 1 | 0.5 | 1 | 0.5 | ||
| 19F (4) | 2 | 1.4 | 2 | 0.9 | 0 | 0.0 | 0 | 0.0 | ||
| 97 | 22 | 10A (22) | 2 | 1.5 | 5 | 2.4 | 8 | 4.0 | 7 | 3.3 |
| 260 | 18 | 3 (18) | 2 | 1.5 | 7 | 3.3 | 7 | 3.5 | 2 | 1.0 |
| 230 | 17 | 24F (14) | 0 | 0.0 | 3 | 1.4 | 3 | 1.5 | 8 | 3.8 |
| 19A (3) | 0 | 0.0 | 1 | 0.5 | 0 | 0.0 | 2 | 1.0 | ||
| 433 | 15 | 22F (15) | 1 | 0.7 | 7 | 3.2 | 2 | 1.0 | 5 | 2.4 |
| 320 | 14 | 19A (14) | 0 | 0.0 | 1 | 0.5 | 6 | 3.0 | 7 | 3.3 |
| 1684 | 23 | 31 (23) | 1 | 0.7 | 5 | 2.4 | 4 | 2.0 | 13 | 6.2 |
| 88 | 11 | 19F (11) | 5 | 3.7 | 3 | 1.4 | 3 | 1.5 | 0 | 0.0 |
| 558 | 11 | 35B (8) | 1 | 0.7 | 2 | 0.9 | 4 | 2.0 | 1 | 0.5 |
| 35F (3) | 1 | 0.7 | 2 | 0.9 | 0 | 0.0 | 0 | 0.0 | ||
| 3548 | 10 | 31 (10) | 1 | 0.7 | 5 | 2.4 | 4 | 2.0 | 0 | 0.0 |
| 717 | 11 | 33F (10) | 3 | 2.2 | 2 | 0.9 | 5 | 2.5 | 1 | 0.5 |
| 191 | 10 | 7 (10) | 1 | 0.7 | 5 | 2.4 | 3 | 1.5 | 1 | 0.5 |
| 67 | 10 | 9L/N (9), 14 (1) | 2 | 1.5 | 1 | 0.5 | 2 | 1.0 | 5 | 2.4 |
| 432 | 8 | 21 (8) | 2 | 1.5 | 4 | 1.9 | 2 | 1.0 | 0 | 0.0 |
| 338 | 18 | 23B (8) | 2 | 1.5 | 2 | 0.9 | 6 | 3.0 | 8 | 3.8 |
| 989 | 7 | 12F (7) | 1 | 0.7 | 4 | 1.9 | 2 | 1.0 | 0 | 0.0 |
| 110 | 7 | 18C (7) | 4 | 2.9 | 2 | 0.9 | 0 | 0.0 | 1 | 0.5 |
| 1201 | 6 | 19A (6) | 1 | 0.7 | 3 | 1.4 | 2 | 1.0 | 0 | 0.0 |
| 392 | 6 | 17F (6) | 0 | 0.0 | 1 | 0.5 | 4 | 2.0 | 1 | 0.5 |
| 1262 | 6 | 15BC (6) | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 6 | 2.9 |
| 177 | 5 | 19F (5) | 1 | 0.7 | 0 | 0.0 | 4 | 2.0 | 0 | 0.0 |
| 90 | 5 | 6B (4) | 3 | 2.2 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 |
| 19F (1) | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 0.5 | ||
Note: Data of the historical period were previously published in part in Domenech et al.1
Abbreviation: AE-COPD, acute exacerbation of chronic obstructive pulmonary disease.