Table 3.
Interventions of the included studies
| Study | Drugs and dosage of TACE/chemotherapy | Course(s) |
|---|---|---|
| Fan et al (2001)20 | 5-Fluorouracil (1,000 mg) + mitomycin (12–20 mg) + cisplatin/carboplatinum (80 mg) + lipiodol (5 mL) | 1–3 courses of TAI or TACE (median: 1.5 courses) (n=11); 2–4 courses (median: 2.5 courses) of HAI and/or PVC or hepatic arterial chemoembolization (n=21) |
| Niguma et al (2005)22 | Cisplatin (5–10 mg on days 1–5/7) + 5-fluorouracil (250 mg for 24 hours on days 1–5/7) | Every 2–3 weeks, a total of four serial courses |
| Cheng et al (2005)26 | Lipiodol (10–20 mL) + 5-fluorouracil (500 mg/m2) + adriamycin (30 mg/m2) + gelatin sponge | 1 course, 1.5 months after surgery |
| Li et al (2006)23 | TACE: lipiodol (10 mL) + doxorubicin (3 mg) + mitomycin (20 mg) + cisplatin (80–100 mg)/carboplatin (400 mg) PVC: NS (500 mL) + 5-fluorouracil (1.5 g), continuous drip in portal vein by infusion pump (4–6 hours) | TACE: once per 2–3 weeks, a total of 2–3 courses, 4 weeks after surgery PVC: once a week for 3 weeks, then once per 3 weeks, a total of 2–3 courses, 2 weeks after surgery |
| Liang et al (2008)21 | 5-Fluorouracil (400–600 mg/m2) + doxorubicin (40–60 mg/m2) + cisplatin (20–40 mg/m2) + IFN-a (5 MU/m2) | 8–14 days after the surgery; 4 days in a course and repeated every 4 weeks, with a maximum of four courses |
| Peng et al (2009)24 | Lipiodol (10–20 mL) + 5-fluorouracil (500 mg/m2) + adriamycin (30 mg/m2) + gelatin sponge | Repeated once every 1–2 months for 2–5 cycles, 3–4 weeks after surgery |
| Zhou et al (2011)19 | 5-Fluorouracil (500 mg/m2) + adriamycin (30 mg/m2) | Every 2 months after postoperative 1 year |
| Ma et al (2013)25 | Lipiodol (10–20 mL) + doxorubicin (30–50 mg) + cisplatin (50–100 mg) | Mean: 2.1 courses (1–6 courses) |
Abbreviations: HAI, hepatic artery infusion; IFN-a, interferon alpha; NS, normal saline; PVC, portal vein chemotherapy/chemobiotherapy; TACE, transarterial chemoembolization; TAI, transarterial infusion.