Table S1.
Drug costs used in the model
| Drug | Pack size | Pack cost | Cost per dose |
|---|---|---|---|
| Roflumilast | |||
| Roflumilast 500 µg | 30 | £37.71 | £1.26 |
| Roflumilast 500 µg | 90 | £113.14 | £1.26 |
| Average cost | |||
| LAMA | |||
| Tiotropium bromide 18 µg | 30 | £33.50 | £1.12 |
| ICS/LABA | |||
| Budesonide/formoterol fumerate dihydrate (200/6) (x2) | 120 | £38.00 | £0.63 |
| Budesonide/formoterol fumerate dihydrate (400/12) | 60 | £38.00 | £0.63 |
| Fluticasone propionate/salmetrol 500 | 60 | £40.92 | £0.68 |
| Average cost (x2)a | £1.30 | ||
| Prednisoloneb | |||
| Prednisolone 5 mg | 28 | £1.24 | £0.04 |
| Prednisolone 25 mg | 56 | £75.00 | £1.34 |
| Combined cost (30 mg dose) | £1.38 | ||
|
| |||
| Monthly drug costs | |||
|
| |||
| Drug | Average cost per pill/tablet | Days of treatment | Cost per month |
|
| |||
| Roflumilast | £1.26 | 30.42c | £38.24 |
| LAMA | £1.12 | 30.42c | £33.97 |
| ICS/LABA | £1.30 | 30.42c | £39.51 |
| Prednisolone 30 mg | £1.38 | 7 | £9.69 |
| Prednisolone 30 mg | £1.38 | 14 | £19.37 |
Notes:
a
Unit costs doubled to ensure correct dosage.
b
Lowest bill burden for patients via this combination.
c
Number of days in each model cycle equivalent to 365/12.
Abbreviations: ICS, inhaled corticosteroid; LABA, long-acting beta-2 agonist; LAMA, long-acting muscarinic receptor antagonist.