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. Author manuscript; available in PMC: 2018 Sep 7.
Published in final edited form as: Processes (Basel). 2018 Apr 25;6(5):42. doi: 10.3390/pr6050042

Figure 5.

Figure 5.

MiR-140 can regulate DFFA in MCF-7, but not MDA-MB-231. (A) Alignment of 21 nt segments of six RNA-Seq reads (three from each cell line) to a portion of the apoptosis inducing gene DFFA. Our edit identification algorithm identified an A-to-G edit site at basepair 10,460,668 on Chromosome 1, and corresponding reads mapping to that location were extracted and trimmed to 21 bp (edit site plus/minus 10 bp flanking regions). Edit location is outlined in red. The alignment was generated via ClustalW [40]. (B) Illustration showing complimentary base pairing between the miR-140 seed (blue) and the DFFA gene in both cell lines. The edit site is indicated in green.