Table 2.

Proportion of the population at three-, four- and fivefold increased risk for each of the five common diseases

High GPS definition	Individuals in testing dataset ( n )	% of individuals
Odds ratio ≥3.0
CAD	23,119/288,978	8.0
Atrial fibrillation	17,627/288,978	6.1
Type 2 diabetes	10,099 288,978	3.5
Inflammatory bowel disease	9,209 288,978	3.2
Breast cancer	2,369/157,895	1.5
Any of the five diseases	57,115/288,978	19.8
Odds ratio ≥4.0
CAD	6,631/288,978	2.3
Atrial fibrillation	4,335/288,978	1.5
Type 2 diabetes	578/288,978	0.2
Inflammatory bowel disease	2,297/288,978	0.8
Breast cancer	474/157,895	0.3
Any of the five diseases	14,029/288,978	4.9
Odds ratio ≥5.0
CAD	1,443/288,978	0.5
Atrial fibrillation	2,020 288,978	0.7
Type 2 diabetes	144/288,978	0.05
Inflammatory bowel disease	571/288,978	0.2
Breast cancer	158/157,895	0.1
Any of the five diseases	4,305/288,978	1.5

For each disease, progressively more extreme tails of the GPS distribution were compared with the remainder of the population in a logistic regression model with disease status as the outcome, and age, sex, the first four principal components of ancestry, and genotyping array as predictors. The breast cancer analysis was restricted to female participants.