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. 2018 Aug 28;10(8):2136–2147. doi: 10.18632/aging.101537

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Copyright © 2018 Kolosova et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of p62 DNA on p62 expression in the retina of OXYS rats at 3 and 13.5 months. (A) Representative p62 immunofluorescence of retinal cryosections from 3- and 13.5-month-old OXYS rats treated by PBS (left) or p62DNA plasmid (right). Scale bar: 50 μm. RPE: retinal pigment epithelium; ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cells layer. (B) Representative immunoblots of p62 in the retina of OXYS rats. 1 - PBS; 2 - p62DNA. (C) Levels of p62 protein by immunoblot. (D) Measurements of retinal thickness (from ONL to GCL) in 3- and 13.5-month-old OXYS rats treated by p62DNA or PBS. *p < 0.05, statistically significant effect of p62DNA; #p < 0.05 between 3 and 13.5 months. Data are presented as mean ± SEM.