Table 3. Risk Factors for Melanoma in a Multivariable Analysis.

Variablea	Males		Females
	AORb (95% CI)	P Value	AORb (95%CI)	P Value
Combination of MC1R Variantsc
R/R	0.92 (0.45-1.89)	.82	1.45 (0.72-2.93)	.40
R/r	1.57 (0.91-2.71)	.11	2.56 (1.52-4.32)	<.001
R/0	1.19 (0.77-1.85)	.43	1.67 (1.07-2.60)	.02
r/r	1.28 (0.71-2.33)	.41	1.53 (0.85-2.76)	.15
r/0	0.74 (0.50-1.10)	.14	1.54 (1.05-2.25)	.02
0/0d	1 [Reference]		1 [Reference]
Freckling face
Moderate to severe	0.94 (0.53-1.68)	.85	NA
Mild	1.01 (0.61-1.68)	.97	NA
None	1 [Reference]		NA
Freckling back
Moderate to severe	1.11 (0.61-2.02)	.73	1.24 (0.73-2.13)	.43
Mild	0.85 (0.50-1.44)	.54	1.48 (0.94-2.32)	.09
None	1 [Reference]		1 [Reference]
Freckling hands
Moderate to severe	0.87 (0.49-1.55)	.63	1.22 (0.67-2.23)	.52
Mild	0.69 (0.46-1.03)	.07	1.37 (0.95-1.99)	.09
None	1 [Reference]		1 [Reference]
Wrinkling face
Moderate to severe	1.13 (0.57-2.23)	.72	0.44 (0.24-0.80)	.007
Mild	1.14 (0.64-2.02)	.66	0.88 (0.54-1.42)	.59
None	1 [Reference]		1 [Reference]
Wrinkling neck
Moderate to severe	2.17 (1.23-3.82)	.007	2.75 (1.61-4.70)	<.001
Mild	1.53 (0.93-2.50)	.09	1.89 (1.27-2.81)	.002
None	1 [Reference]		1 [Reference]
Solar lentigines face
Moderate to severe	1.36 (0.78-2.36)	.28	1.01 (0.60-1.71)	.96
Mild	2.39 (1.57-3.64)	<.001	1.56 (1.06-2.28)	.02
None	1 [Reference]		1 [Reference]
Solar lentigines back
Moderate to severe	2.56 (1.47-4.45)	.001	1.90 (1.14-3.15)	.01
Mild	1.92 (1.18-3.11)	.008	1.46 (0.96-2.22)	.08
None	1 [Reference]		1 [Reference]
Solar lentigines hand
Moderate to severe	2.31 (1.24-4.29)	.008	1.27 (0.71-2.26)	.41
Mild	1.32 (0.83-2.11)	.24	1.03 (0.66-1.61)	.88
None	1 [Reference]		1 [Reference]
Sunburns in life
≥20	1.65 (1.12-2.42)	.01	1.89 (1.29-2.76)	.001
2-19	1.23 (0.84-1.79)	.29	0.96 (0.68-1.36)	.83
0-1	1 [Reference]		1 [Reference]

Abbreviations: AOR, adjusted odds ratio; NA, not applicable.

^aOnly variables that remained significant in the univariate analysis were included in the multivariate analysis.

^bAdjusted for age.

^cR = 86_87insA, R142H, R151C, R160W, D294H, D84E; r = V60L, V92M, I155T, R163Q.

^dParticipants who did not carry any “r” or “R.”