Figure. Semantic Connectivity Map of Important Players in Hidradenitis Suppurativa (HS) Pathogenesis.

The map shows the best associations (in a normalized range between 0 and 1) among variables in lesional HS skin. Continuous variables were categorized as high (hi) vs low values based on their medians. Direct lines show the strongest positive associations, while spatial proximity between variables also indicates patterns of direct correlations. hBD-2 indicates human β-defensin 2; IFNγ, interferon γ; IL-1α, interleukin 1α; inflammatory score, mean of the scores of T cells, macrophages, and neutrophils; TNF, tumor necrosis factor.