Table 1. Dermatologist and Patient Ratings of Mean Detectability of Hyaluronic Acid Filler Buttonsa.
| Hyaluronidase Dose | Detectability,b Mean (SD) | ||||
|---|---|---|---|---|---|
| Baseline (Week 1) |
Week 2 | Week 3 | Follow-up (Week 4) |
Follow-up (Month 4) | |
| Dermatologists | |||||
| Visual detection | |||||
| Restylane-L | |||||
| Saline | 3.89 (0.33) | 2.67 (0.87) | 2.33 (0.87) | 2.11 (1.27) | 1.11 (0.33) |
| 1.5 U | 3.67 (1.00) | 2.44 (0.88) | 1.89 (0.33) | 1.78 (1.20) | 1.22 (0.67) |
| 3.0 U | 3.78 (0.44) | 2.22 (1.39) | 1.89 (1.05) | 1.78 (1.20) | 0.89 (1.05) |
| 9.0 U | 3.67 (0.71) | 1.78 (0.97) | 0.89 (0.78) | 0.89 (1.36) | 0.44 (0.73) |
| Juvéderm Ultra XC | |||||
| Saline | 3.78 (0.44) | 3.00 (0.87) | 3.00 (1.00) | 3.00 (0.87) | 1.89 (1.05) |
| 1.5 U | 3.67 (0.71) | 2.00 (1.00) | 1.33 (1.12) | 0.89 (1.17) | 0.22 (0.67) |
| 3.0 U | 3.78 (0.44) | 2.33 (0.71) | 1.67 (0.50) | 1.78 (0.83) | 0.89 (0.78) |
| 9.0 U | 3.67 (0.71) | 2.11 (0.93) | 1.44 (0.73) | 1.33 (1.41) | 0.56 (1.01) |
| Palpability | |||||
| Restylane-L | |||||
| Saline | 3.89 (0.33) | 3.22 (0.97) | 2.78 (0.83) | 2.33 (1.00) | 1.11 (0.60) |
| 1.5 U | 3.78 (0.67) | 2.67 (0.71) | 2.11 (0.93) | 1.89 (0.930 | 1.11 (0.60) |
| 3.0 U | 3.89 (0.33) | 2.67 (1.12) | 2.00 (0.87) | 1.67 (1.12) | 0.78 (0.97) |
| 9.0 U | 3.67 (0.71) | 2.00 (0.71) | 1.00 (0.87) | 0.67 (1.32) | 0.22 (0.44) |
| Juvéderm Ultra XC | |||||
| Saline | 3.78 (0.44) | 3.22 (0.97) | 3.11 (1.05) | 2.89 (1.17) | 1.67 (1.12) |
| 1.5 U | 3.67 (0.71) | 2.56 (1.24) | 1.33 (0.87) | 1.22 (1.20) | 0.33 (0.71) |
| 3.0 U | 3.67 (0.50) | 2.56 (0.73) | 1.78 (0.67) | 1.56 (0.88) | 0.56 (0.53) |
| 9.0 U | 3.56 (0.73) | 2.22 (0.67) | 1.44 (1.01) | 1.33 (1.22) | 0.44 (1.01) |
| Patients | |||||
| Visual detection | |||||
| Restylane-L | |||||
| Saline | 3.44 (0.88) | 2.78 (1.39) | 2.56 (1.13) | 2.22 (1.20) | 1.89 (0.93) |
| 1.5 U | 3.67 (0.50) | 2.11 (0.93) | 2.00 (0.71) | 1.89 (0.93) | 1.56 (1.13) |
| 3.0 U | 3.44 (0.73) | 2.11 (1.05) | 2.00 (0.71) | 1.78 (0.97) | 1.11 (0.93) |
| 9.0 U | 3.44 (0.73) | 1.67 (1.00) | 1.44 (1.33) | 1.44 (1.42) | 0.56 (0.88) |
| Juvéderm Ultra XC | |||||
| Saline | 3.22 (0.97) | 2.67 (1.12) | 2.67 (1.00) | 2.44 (1.59) | 2.44 (1.24) |
| 1.5 U | 3.00 (1.12) | 1.44 (1.01) | 1.44 (1.01) | 1.22 (1.09) | 0.44 (0.73) |
| 3.0 U | 3.22 (0.83) | 2.00 (0.87) | 1.78 (1.09) | 1.22 (0.97) | 1.11 (1.36) |
| 9.0 U | 3.44 (0.73) | 1.44 (0.73) | 1.56 (1.01) | 1.22 (0.83) | 0.33 (0.50) |
| Palpability | |||||
| Restylane-L | |||||
| Saline | 3.33 (1.00) | 3.00 (1.00) | 2.67 (1.22) | 2.33 (1.22) | 2.00 (1.12) |
| 1.5 U | 3.67 (0.71) | 2.11 (0.78) | 1.56 (0.73) | 1.11 (0.78) | 1.11 (0.78) |
| 3.0 U | 3.56 (0.73) | 2.22 (1.09) | 1.44 (1.01) | 1.56 (1.13) | 0.67 (0.87) |
| 9.0 U | 3.22 (1.09) | 1.67 (0.71) | 0.78 (1.39) | 0.78 (0.97) | 0.22 (0.67) |
| Juvéderm Ultra XC | |||||
| Saline | 3.11 (1.17) | 3.33 (0.87) | 2.89 (1.17) | 2.78 (1.30) | 2.22 (0.97) |
| 1.5 U | 2.89 (1.36) | 2.33 (1.22) | 1.11 (0.78) | 0.89 (0.93) | 0.44 (0.73) |
| 3.0 U | 3.00 (1.12) | 2.00 (1.12) | 2.00 (1.32) | 1.11 (1.05) | 0.89 (1.27) |
| 9.0 U | 3.11 (0.93) | 1.89 (1.45) | 1.11 (0.93) | 0.33 (0.50) | 0.22 (0.44) |
a
Juvéderm Ultra XC, Allergan Inc; or Restylane-L, Galderma Laboratories.
b
Detectability was rated on a 5-point scale as follows: 0 = undetectable, 1 = faintly perceptible, 2 = mildly perceptible, 3 = moderately perceptible, 4 = very perceptible.