Table 2. The profile of the top 20 up-regulated and down-regulated pathways in KEGG Orthologue database.

Type of regulation	Pathway	Rich factor	Adjusted p-value	Gene number	Function description
Up-regulated	Acute myeloid leukaemia	0.275	0.3628	11	Cancers
	Axon guidance	0.186	0.3936	29	Development
	B cell receptor signalling pathway	0.316	0.1962	12	Immune system
	Bacterial invasion of epithelial cells	0.230	0.1962	23	Infectious diseases
	Chemokine signalling pathway	0.222	0.1962	28	Immune system
	Dopaminergic synapse	0.210	0.3432	22	Nervous system
	Endocytosis	0.163	0.5257	46	Transport and catabolism
	ErbB signalling pathway	0.205	0.5257	16	Signal transduction
	Fc gamma R-mediated phagocytosis	0.241	0.1962	21	Immune system
	Focal adhesion	0.205	0.1935	44	Cellular Process
	Hedgehog signalling pathway	0.250	0.3432	14	Signal transduction Processing
	Hedgehog signalling pathway—fly	0.257	0.5257	9	Signal transduction
	Insulin signalling pathway	0.172	0.5257	30	Endocrine system
	PI3K-Akt signalling pathway	0.163	0.5257	38	Signal transduction
	Platelet activation	0.180	0.5257	27	Cancer
	Prolactin signalling pathway	0.255	0.3936	12	Endocrine system
	Proteoglycans in cancer	0.186	0.2138	42	Cancer
	Regulation of actin cytoskeleton	0.206	0.1935	41	Cellular Process
	Salmonella infection	0.221	0.2981	21	Disease
	Shigellosis	0.242	0.1962	22	Disease
Down- regulated	Adipocytokine signalling pathway	0.088	0.201	6	Endocrine system
	alpha-Linolenic acid metabolism	0.182	0.030	6	Lipid metabolism
	Arachidonic acid metabolism	0.182	0.002	10	Lipid metabolism
	Arginine and proline metabolism	0.123	0.026	9	Amino acid metabolism
	Ascorbate and aldarate metabolism	0.167	0.129	4	Carbohydrate metabolism
	Citrate cycle (TCA cycle)	0.098	0.160	6	Carbohydrate metabolism
	Ether lipid metabolism	0.122	0.085	6	Lipid metabolism
	Fat digestion and absorption	0.161	0.085	5	Digestive system
	Fatty acid degradation	0.084	0.173	7	Lipid metabolism
	Glutathione metabolism	0.096	0.085	8	Metabolism
	Glycolysis / Gluconeogenesis	0.069	0.160	10	Carbohydrate metabolism
	Linoleic acid metabolism	0.235	0.002	8	Lipid metabolism
	Pancreatic secretion	0.087	0.085	9	Digestive system
	Parkinson’s disease	0.052	0.302	13	Neurodegenerative diseases
	Protein digestion and absorption	0.094	0.224	5	Digestive system
	Pyruvate metabolism	0.080	0.201	7	Carbohydrate metabolism
	Starch and sucrose metabolism	0.087	0.201	6	Carbohydrate metabolism
	Steroid hormone biosynthesis	0.120	0.348	3	Lipid metabolism
	Valine, leucine and isoleucine degradation	0.094	0.085	8	Amino acid metabolism
	Vascular smooth muscle contraction	0.067	0.201	9	Circulatory system