Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Leukemia. 2017 Oct 3;32(4):960–970. doi: 10.1038/leu.2017.304

Table 1.

Patient characteristics

Age Sex #
prior
Rx
FISH Baseline
B2M
IGHV
MS
Largest lymph
node pre-
treatment (cm)
Rai
stage
Infection Response Progression CD4+PD1+
T cells [%]
CD8+PD1+
T cells [%]
CD19+
CD5+PD1+ [%]
CD19+
CD5+PDL1+ [%]
CD19+CD5+
p-S727-STAT3
[MFI]
IgG
pre 3mo 6mo pre 3mo 6mo pre 3mo 6mo pre 3mo 6mo pre 3mo 6mo pre
55 F 1 Del(17p) 2.5 NR 2.9 4 PR 38.0 27.5 NA 26.4 13.9 NA 64.6 11.9 NA 22 25.8 NA 992 358 381 566
57 M 1 Del(11q) 3.5 NR 6.3 3 PR 45.9 44.1 NA 13.9 9.7 NA 31.7 42.5 NA 34.1 15.7 NA NA NA NA 692
59 F 3 Del(17p) 3.8 UM 5.5 4 CR 27.2 14.5 NA 21.3 10.1 NA 39.2 3.3 NA 12.4 5 NA 375 NA 180 383
60 M 1 Del(11q) 2.6 UM 3.6 1 PR 31.2 NA 24.1 30.3 NA 21.8 54.1 NA 1 8.5 NA 19.3 NA NA NA 521
63 M 2 Del(17p) 4.4 MUT 7.9 1 PR 40.7 43.6 NA 28.3 30.9 15.5 1.2 NA 6.6 6.8 NA 256 214 NA 417
64 M 0 Del(17p) 14.0 UM 9.1 3 URI Grade 2 PR 42.0 40.6 40.9 19.8 20.5 15.8 8.4 0.7 0.6 18 9.7 8.1 NA NA NA 2380*
64 F 6 Del(11q) 9.3 MUT 2.8 4 PR 78.5 54.7 49.6 35.8 6.2 6.5 3.9 2.8 1.5 5.8 11.5 5.5 528 217 199 60
68 M 2 Del(17p) 6.3 UM 5.4 4 PR 17.6 15.8 15.8 15.0 9.9 12.7 6.9 1.5 3.3 9.8 6.2 8.2 322 119 172 444
68 M 1 Del(17p) 4.9 UM 5.4 2 PR 11m 19.1 13.2 NA 17.1 9.4 NA 10.6 0.3 NA 51.3 54.4 NA NA NA NA 369
70 M 2 Neg 4.5 UM 3.4 1 PR 25.4 20.9 NA 19.8 7.3 NA 24.2 4.1 NA 16.5 14.6 NA NA NA NA 567
71 F 3 Trisomy 12 5.1 UM 3.0 4 Cryptococcal meningitis Grade 4 PR 54.4 40.5 36.5 8.6 6.4 6 1.05 0.2 0.4 22.2 21.8 NA 587 338 NA 1828
71 M 0 Del(13q) 3.7 UM 11.3 1 PR 14.1 7.5 NA 26.3 19.7 NA 9.18 0.2 NA 13.2 0 NA 348 200 191 795
72 F 0 Del(13q) 2.8 MUT 2.0 3 CR 12.6 15.6 NA 35.4 36.2 NA 4.7 1.2 NA 23 14.7 NA 191 170 156 387
73 F 1 Del(17p) 9.1 MUT 3.8 3 Pneumonia Grade 3 PR 20m 7.2 9.43 NA 19.8 19.0 NA 14.4 4.3 NA 5.9 2.6 6.4 NA NA NA 97
74 M 1 Del(17p) 4.5 MUT 3.8 4 PR 31m 40.2 41.8 NA 28.4 19.7 NA 5.5 0.6 NA 38.8 22.9 NA NA NA NA 849
79 F 5 Del(13q) 4.5 MUT 5.6 4 URI Grade 2 PR 43.4 41.2 41.5 23.8 25.8 23.4 88.1 40.2 40.5 15.1 5.1 8 389 200 235 1194
79 M 3 Neg 3.5 MUT 4.4 3 PR 26.3 NA 29.8 14.9 NA 15 5.6 NA 19 12.2 7 NA NA NA NA 1100

Abbreviations: B2M: β2-microglobulin; FISH, fluorescence in situ hybridization; IGHV MS, immunoglobulin heavy chain variable mutation status; 3m, after 3 months of treatment; # prior Rx, number of prior therapies; PR, partial remission; CR, complete remission; NA, not available.