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EGFR signalling suppresses IFNγ/TNFα related production of T cell attracting cytokines, including CCL5, CXCL9 and CXCL10 mainly through activation of JNK and MEK1 signaling. Inhibition of EGFR signaling with cetuximab, JNK inhibitor SP600125 and/or MEK1 inhibitor PD98059, restores the IFNγ/TNFα stimulated production of T cell attracting cytokines.
