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| Vmax (nmol/mg protein•6 sec) |
Km (mM) |
|
|---|---|---|
| Control | 3.4 ± 0.1 | 24 ± 0.6 |
| Inflamed | 1.9 ± 0.2* | 27.2± 1.2 |
| Inflamed + PRX | 3.3 ± 0.1* | 23.3 ± 1.6 |
PRX treatment reversed the maximal rate of uptake (Vmax) of Na-glutamine co-transport which was significantly diminished in chronically inflamed intestine (n = 3, *p<0.05). The affinity of the BBM Na-glutamine co-transporters remained unchanged in all conditions.
