Table 2. Blood and CSF cytokines of HTLV-1 infected individuals.
| GROUPS | AG (N = 21) | SG (N = 11) | HG (N = 15) | ||||
|---|---|---|---|---|---|---|---|
| Plasma (pg/ml) | Mean (SD) | Me | Mean (SD) | Me | Mean (SD) | Me | pa |
| ITAC | 11.3(8.8) | 8.8 | 10.0(5.0) | 8.3 | 16.3(8.6) | 15.2 | 0.003 |
| GMCSF | 28(63) | 6.5 | 19.1(16.2) | 13.5 | 14.1(12.7) | 9.4 | 0.395 |
| Fracktalkine | 66(36) | 68.5 | 57.1(26.2) | 52.7 | 53.0(21.1) | 50.1 | 0.241 |
| INF-gamma | 7.7(11.7) | 5.3 | 5.6(2.7) | 5.8 | 4.6(1.9) | 4.2 | 0.193 |
| IL-10 | 1.1(0.5) | 0.9 | 1.1(0.6) | 0.9 | 1.0(0.6) | 0.7 | 0.652 |
| Mip3alpha | 4.5(1.9) | 3.7 | 4.5(2.2) | 3.8 | 3.7(0.5) | 3.8 | 0.289 |
| IL-12p70 | 1.2(1.1) | 0.7 | 0.8(0.8) | 0.4 | 1.7(1.1) | 1.9 | 0.035 |
| IL-13 | 2.1(1.8) | 1.7 | 1.9(1.2) | 1.7 | 1.7(1.5) | 1.3 | 0.665 |
| IL-17-A | 5.5(3.3) | 4.7 | 5.0(3.0) | 4.5 | 3.5(1.6) | 3.1 | 0.027 |
| IL-1beta | 0.6(0.4) | 4.9 | 0.6(0.2) | 0.6 | 0.6(0.1) | 0.6 | 0.079 |
| IL-2 | 1.9(1.8) | 1.1 | 1.7(1.0) | 1.2 | 2.0(1.1) | 1.5 | 0.172 |
| IL-21 | 2.0(4.9) | 0.7 | 0.8(0.5) | 0.9 | 0.8(0.4) | 0.7 | 0.987 |
| IL-4 | 3.1(3.1) | 1.7 | 2.3(1.7) | 2.2 | 1.8(1.1) | 1.4 | 0.360 |
| IL-23 | 71(41) | 67.7 | 67.1(29) | 58.2 | 62.8(19.1) | 60.8 | 0.552 |
| IL-5 | 0.6(0.5) | 0.4 | 0.7(0.3) | 0.5 | 0.5(0.2) | 0.4 | 0.724 |
| IL-6 | 0.7(0.4) | 0.7 | 0.7(0.5) | 0.6 | 1.0(0.6) | 1.0 | 0.065 |
| IL-7 | 1.0(1.3) | 0.3 | 0.4(0.4) | 0.2 | 0.7(0.6) | 0.3 | 0.630 |
| IL-8 | 2.3(1.4) | 2.0 | 2.1(1.5) | 1.5 | 2.0(0.9) | 2.0 | 0.343 |
| TNF-alpha | 0.9(0.8) | 0.6 | 0.5(0.2) | 0.5 | 0.8(0.6) | 0.7 | 0.797 |
| CSF (pg/ml) | AG (N = 21) | SG (N = 11) | HG (N = 14) | ||||
| ITAC | 58.3(32.3) | 51.7 | 55(32.3) | 44.4 | 117(64.2) | 100.5 | 0.002 |
| GMCSF | 0.7(0.2) | 0.7 | 0.8(0.2) | 0.8 | 0.8(0.3) | 0.7 | 0.317 |
| Fracktalkine | 141(32.8) | 131.5 | 155(26.1) | 148.1 | 134(32.2) | 142.7 | 0.489 |
| INF-gamma | 1.0(0.9) | 0.6 | 1.8(1.7) | 0.6 | 3.0(3.3) | 2.0 | 0.043 |
| IL-10 | 4.3(2.8) | 4.4 | 4.8(5.8) | 2.7 | 5.3(2.4) | 5.4 | 0.250 |
| Mip3alpha | 33.0(6.5) | 31.8 | 30.9(5.7) | 32.8 | 30.8(7.7) | 28.5 | 0.207 |
| IL-12p70 | 1.1(0.9) | 0.8 | 1.0(0.5) | 0.8 | 1.6(1.0) | 1.2 | 0.108 |
| IL-13 | 4.3(2.5) | 5.0 | 5.4(2.2) | 5.7 | 4.2(2.7) | 5.1 | 0.879 |
| IL-17-A | 0.3(0.4) | 0.3 | 0.2(0.1) | 0.2 | 0.2(0.1) | 0.2 | 0.574 |
| IL-1beta | 0.3(0.4) | 0.2 | 0.3(0.5) | 0.3 | 0.3(0.02) | 0.3 | 0.574 |
| IL-2 | 1.1(0.3) | 1.2 | 1.1(0.7) | 1.2 | 1.3(0.4) | 1.2 | 0.288 |
| IL-21 | 3.0(2.1) | 2.3 | 3.7(1.4) | 3.9 | 3.0(1.8) | 3.6 | 0.892 |
| IL-4 | 0.6(0.4) | 0.4 | 0.3(0.1) | 0.4 | 0.5(1.2) | 0.4 | 1.000 |
| IL-23 | 29.2(15.7) | 25.2 | 40.5(18.2) | 37.8 | 32.6(20.0) | 34.6 | 0.623 |
| IL-5 | 3.2(1.1) | 2.9 | 3.3(1.0) | 2.9 | 3.7(0.8) | 3.8 | 0.012 |
| IL-6 | 5.6(2.7) | 5.0 | 5.0(1.5) | 5.4 | 4.7(1.2) | 4.4 | 0.189 |
| IL-7 | 6.9(5.3) | 6.3 | 7.6(4.5) | 7.9 | 8.6(5.1) | 8.7 | 0.521 |
| IL-8 | 25.8(5.3) | 25.0 | 26.0(6.0) | 25.6 | 30.5(5.8) | 29.6 | 0.010 |
| TNF-alpha | 0.8(0.9) | 0.4 | 0.6(0.4) | 0.7 | 1.5(0.9) | 1.5 | 0.015 |
aKruskal-Wallis Test; SD—Standard deviation;; Me—median; AG—Asymptomatic Group; SG- Symptomatic Group; HG- HAM/TSP Group; CSF—Cerebrospinal Fluid.