Table 1.
The composition of different Cl cubosome formulae.
| F | 5%(w/w) GMO/PF127* |
%Stabilizer** |
||
|---|---|---|---|---|
| GMO* | PF127* | PVA | Ethanol | |
| CA | 97.5 | 2.5 | 0 | – |
| C2 | 95 | 2.5 | 2.5 | – |
| C3 | 92.5 | 2.5 | 5 | – |
| C4 | 95 | 5 | 0 | – |
| C5 | 92.5 | 5 | 2.5 | – |
| C6 | 90 | 5 | 5 | – |
| C7 | 90 | 10 | 0 | – |
| C8 | 87.5 | 10 | 2.5 | – |
| C9 | 85 | 10 | 5 | – |
| C10 | 95 | 2.5 | – | 2.5 |
| C11 | 92.5 | 2.5 | – | 5 |
| C12 | 92.5 | 5 | – | 2.5 |
| C13 | 90 | 5 | – | 5 |
| C14 | 87.5 | 10 | – | 2.5 |
| C15 | 85 | 10 | – | 5 |
Notes: The drug is solubilized in the organic phase.
All formulae contain; 0.25% (w/w) clonazepam 95% (w/w) water.
*
The GMO/PF127 concentration is constant 5%w/w of the total Cubosome weight.
**
The stabilizer concentration is (w/w) percentage form the disperse phase.