Table 1.

Parameters of gravid female rats administered KACY.

Parameter	Reproductive performance from GD6 to GD15 (dose in mg/kg)
	Control	ASA 250	KACY 50	KACY 250	KACY 500	KACY 1000
No. of mated females	15	15	15	15	15	15
No. of pregnant females	15	15	15	15	15	15
Pregnancy index (%)	100	100	100	100	100	100
Fertility index (%)	100	100	100	100	100	100
Maternal weight gain (g) (GD0-19)	132.86 ± 5.68b	56.08 ± 6.06a	127.38 ± 4.78b	111.51 ± 4.77b	97.61 ± 9.06a,b	94.80 ± 10.64a,b
No. of females with live fetuses	15	10a	15b	15b	15b	12
Implantation sites	199	223	198	206	206	217
Implantations/per litter	13.26 ± 0.82	14.86 ± 0.69	13.2 ± 0.83	13.73 ± 0.71	13.73 ± 0.69	14.46 ± 0.60
Live fetuses	178	87a	180b	186b	179b	176b
Live fetuses/litter	11.86 ± 0.78	5.8 ± 0.57	12.00 ± 0.77	12.4 ± 0.55	11.93 ± 0.77	11.33 ± 1.45a
Resorptions and dead fetuses	21	136a	18b	20b	27b	47b
Resorptions and dead fetuses/litter	1.40 ± 0.42	9.06 ± 0.78a	1.20 ± 0.31	1.33 ± 0.37	1.8 ± 0.26b	3.13 ± 1.15a,b
Post-implantation loss/per litter (%)	10.55	60.98a	9.09b	9.70b	13.10b	18.89a,b
Dams with resorptions	9	15a	10	9	13	10

The values are given as the mean ± SEM. ASA = acetylsalicylic acid; KACY = kramecyne. A significant difference (p < 0.05) in relation to the ^acontrol and/or ^bASA at 250 mg/kg.

Pregnancy index = (No. of females with live fetuses/No. of mated females) x 100.

Fertility index = (No. of pregnant females/No. of mated females) × 100.

Post-implantation loss = (No. of implantations - No. of live fetuses/n of implantations) × 100.