Table 4.
Skeletal alterations in the fetuses from female rats administered KACY during days 6 through 15 of gestation.
| Treatment (mg/kg) |
||||||
|---|---|---|---|---|---|---|
| Control | ASA 250 | KACY 50 | KACY 250 | KACY 500 | KACY 1000 | |
| Fetuses analyzed | 55 | 26 | 57 | 58 | 55 | 51 |
| Skull bones | ||||||
| Incomplete ossification in the following bones: | ||||||
| Frontal | 0 (0%) | 14 (54%)a | 5 (9%)b,c | 8 (14%)a,b,c | 18 (33%)a | 23 (45%)a |
| Parietal | 0 (0%) | 14 (54%)a | 5 (9%)b,c | 16 (28%)a,b,c | 37 (67%)a | 31 (61%)a |
| Interparietal | 0 (0%) | 14 (54%)a | 9 (16%)b,c | 11 (19%)a,b,c | 32 (56%)a | 38 (75%)a |
| Exoccipital | 0 (0%) | 18 (69%)a | 5 (9%)b | 2 (3%)b | 4 (7%)b | 2 (4%)b |
| Supraoccipital | 2 (4%) | 21 (81%)a | 4 (7%)b | 4 (7%)b | 3 (5%)b | 5 (10%)b |
| Acrania | 0 (0%) | 9 (35%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Pelvis bones | ||||||
| Incomplete ossification in the following bones: | ||||||
| Pelvis | 18 (33%) | 13 (50%) | 22 (39%) | 21 (36%) | 15 (27%) | 23 (45%) |
| Ilium | 2 (4%) | 7 (27%)a | 0 (%)b | 0 (0%)b | 3 (5%)b | 2 (4%)b |
| Ischium | 3 (5%) | 11 (42%)a | 1 (2%)b | 1 (2%)b | 3 (5%)b | 8 (16%)b |
| Sternum bones | ||||||
| Incomplete ossification in the following bones: | ||||||
| Sternebrae I | 15 (27%) | 1 (4%)a | 17 (30%)b | 21 (36%)b | 25 (45%)b | 25 (49%)a |
| Sternebrae II | 20 (36%) | 2 (8%)a | 35 (61%)b | 38 (66%)b | 29 (53%)b | 36 (71%)a |
| Sternebrae III | 12 (22%) | 3 (12%) | 21 (37%)b | 20 (34%) | 28 (51%)a,b | 26 (51%)a,b |
| Asymmetrical bones: | ||||||
| Sternebrae I | 2 (4%) | 12 (46%)a | 1 (2%)b,c | 6 (10%)b | 5 (9%)b | 13 (25%)a,b |
| Sternebrae II | 1 (2%) | 12 (46%)a | 2 (4%)b,c | 5 (9%)b | 5 (9%)b | 8 (16%)a,b |
| Sternebrae III | 3 (5%) | 12 (46%)a | 2 (4%)b,c | 7 (12%)b | 6 (11%)b | 13 (25%)a,b |
| Fused bones: | ||||||
| Sternebrae I | 0 (0%) | 8 (31%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Sternebrae II | 0 (0%) | 8 (31%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Sternebrae III | 0 (0%) | 8 (31%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Hyperplastic and cleaved bones: | ||||||
| Sternebrae I | 0 (0%) | 5 (19%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Sternebrae II | 0 (0%) | 5 (19%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Sternebrae III | 0 (0%) | 5 (19%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Vertebrae | ||||||
| Cleaved bones: | ||||||
| Cervical | 0 (0%) | 5 (19%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Thoracic | 0 (0%) | 12 (46%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Lumbar | 0 (0%) | 13 (50%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Sacred | 0 (0%) | 1 (4%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Fused bones: | ||||||
| Cervical | 0 (0%) | 3 (12%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Thoracic | 0 (0%) | 4 (15%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Ribs | ||||||
| Cleaved right ribs | 0 (0%) | 10 (38%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Cleaved left ribs | 0 (0%) | 16 (62%)a | 0 (0%)b | 0 (0%)b | 0 (0%)b | 0 (0%)b |
| Extra ribs | 0 (0%) | 1 (4%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Rudimentary right ribs | 1 (2%) | 14 (54%)a | 3 (5%)b | 3 (5%)b | 4 (7%)b | 3 (6%)b |
| Rudimentary left ribs | 1 (2%) | 10 (38%)a | 2 (4%)b | 2 (3%)b | 3 (5%)b | 3 (6%)b |
| Undulate right ribs | 0 (0%) | 4 (15%)a | 0 (0%)b | 0 (0%)b | 1 (2%)b | 3 (6%) |
| Undulate left ribs | 0 (0%) | 4 (15%)a | 0 (0%)b | 1 (2%)b | 2 (4%)b | 2 (4%)b |
Values in parenthesis denote percentages. ASA = acetylsalicylic acid; KACY = kramecyne. Significant difference (p < 0.05) in relation to the acontrol, bASA at 250 mg/kg and/or cKACY at 1000 mg/kg.