Table 1.

Pharmacokinetic parameters of ¹⁴C-C₃ in C57B6 mice

Parametera	dose	t1/2	AUC	k	Cl	V	Tmax	Cmax
Units	mg/kg	hr	μg-hr/mL	1/hr	mL/kg-min	l/kg	min	μg/mL
i.p.	1.1	8.0 ± 0.6	13.9 ± 1.4	0.087 ± 0.007	1.32 ± 0.13	0.91 ± 0.12	60	1.3 ± 0.1
i.v.	1.1	8.2 ± 0.2	15.2 ± 1.4	0.085 ± 0.002	1.20 ± 0.11	0.85 ± 0.08	5	4.0 ± 0.2
i.v.0-1b	1.1	0.8 ± 0.1		0.90 ± 0.12
p.o.	1.1		0.36				60	0.03

^aParameters and formulas are described in the methods section.

^bvalues in the i.v._0-1 row are from data collected within the first hour after C₃ injection. Values are mean ± SEM (n=6).

i.p. = intraperitoneal, i.v. = intravenous, and p.o. = per os,

AUC = area under the curve, Cl = systemic clearance, V= volume of distribution