Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Genes Chromosomes Cancer. 2018 Aug 20;57(10):485–494. doi: 10.1002/gcc.22643

Figure 4.

Figure 4

Expression analysis of HMGA2 mediated AKT alteration in primary ULM cells. A. Overexpression of HMGA2 by lentiviral transduction increases pAKT activity in a dose dependent manner. B. and C. Decreased HMGA2 expression by siRNA was evident by immunofluorescent stain of HMGA2 (B) and down regulation of pAKT occurs as a consequence (C). D. Western blot analysis illustrated that siRNA HMGA2 treatment significantly reduced pAKT, but not total AKT. E. Blocking pAKT activity by AKT inhibitor MK2206 showed minimal effect on HMGA2 expression. * p<0.05, ** p<0.01.