Table II.
Multivariable analysis of aGVHD grade II–IV
| CTN-0201 | CTN-0901 | ||||
|---|---|---|---|---|---|
|
| |||||
| Model | HR (95%CI) | P | Model | HR (95%CI) | P |
|
| |||||
| rs4415345: G vs. C | 0.58 (0.37–0.92) | 0.02 | rs4415345: G vs. C | 1.18 (0.72–1.92) | 0.52 |
| Graft source: PB vs. BM | 1.01 (0.59–1.74) | 0.97 | Conditioning: RI vs. MA | 0.51 (0.21–1.24) | 0.14 |
| Conditioning: RI vs. MA | 1.12 (0.71–1.78) | 0.62 | 0.83 (0.35–2.01) | 0.69 | |
| SNP × Graft source | 1.55 (0.83–2.87) | 0.17 | SNP × Conditioning | ||
|
| |||||
| rs4610776: T vs. A | 1.53 (1.01–2.32) | 0.05 | rs4610776: T vs. A | 0.94 (0.54–1.65) | 0.84 |
| Graft source: PB vs. BM | 1.56 (0.90–2.70) | 0.11 | Conditioning: RI vs. MA | 0.59 (0.29–1.17) | 0.13 |
| Conditioning: RI vs. MA | 1.06 (0.66–1.70) | 0.80 | 0.57 (0.20–1.60) | 0.29 | |
| SNP × Graft source | 0.72 (0.39–1.34) | 0.30 | SNP × Conditioning | ||
|
| |||||
| rs7588571: A vs. G | 0.99 (0.67–1.46) | 0.96 | rs7588571: A vs. G | 1.39 (0.90–2.16) | 0.14 |
| Graft source: PB vs. BM | 1.41 (0.80–2.50) | 0.24 | Conditioning: RI vs. MA | 0.75 (0.36–1.57) | 0.45 |
| Conditioning: RI vs. MA | 1.10 (0.69–1.76) | 0.68 | 0.44 (0.18–1.05) | 0.06 | |
| SNP × Graft source | 0.87 (0.51–1.49) | 0.61 | SNP × Conditioning | ||
BM: Bone marrow; CI: Confidence interval; CTN: Clinical Trials Network;HR: Hazard ratio; MA: Myeloablative; PB: Peripheral blood; RI: Reduced intensity; SNP: Single nucleotide polymorphism