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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Int J Cancer. 2018 Aug 9;143(8):1963–1977. doi: 10.1002/ijc.31586

Figure 3. Medium from sCEA-stimulated HNNFb cultures favors the adherence and expansion of CEA-expressing colonic carcinoma cell lines.

Figure 3.

Medium from sCEA-activated fibroblasts promotes a more rapid adherence of CEA-expressing colorectal cancer cells relative to medium recovered from naïve fibroblasts (0–8 hours; panel A) as well as their increased proliferation and expansion (8–48 hours; panel B). CEA-expressing human colon cancer LS174T and HT-29 were dispensed into E-plate wells pre-treated with medium from either naïve or sCEA-activated fibroblasts. The impact of incubating cancer cells in medium from either naïve or sCEA-activated fibroblasts was monitored as changes in relative electrical impedance (CI) at 1-min intervals, for 48 hours.