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. 2018 Sep 7;8:13442. doi: 10.1038/s41598-018-31713-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo biodistribution study of HAdV17GFP vectors. Viral genomes were measured by qPCR in liver, heart, lung, artery, kidney, pancreas, spleen, intestine and brain 72hrs after systemic administration. 2 × 10e9 transducing units (TU) per mouse of HAdV17GFP were administered intravenously into CD46 transgenic mice and wild type C57BL/6 mice, and the same viral dose of HAdV5GFP was injected into wild type mice serving as control (n = 3 mice per group). (A) Direct comparison of HAdV17GFP and HAdV5GFP in C57CBl/6 wild type mice. (B) Direct comparison of HAdV17GFP in CD46 transgenic and wild type mice. *P < 0.05, **P < 0.01, ***P < 0.001. (C) Neutralizing antibody assay. Reciprocal dilution of dog serum, immunized with HAdV5, was incubated with HAdV17GFP and HAdV5GFP. The serum-virus mixture was used to infect HEK293 cells and 24 hrs post-infection GFP expression levels were determined. **P < 0.01, ***P < 0.001.