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. 2018 Sep 7;8:13472. doi: 10.1038/s41598-018-31534-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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L-Lactate-induced potentiation depends on the redox state of the cell. (A₁,B₁,C₁ and D₁) Intracellular Ca²⁺ signals (average Fura-2 ratio) following 2 successive co-applications of glutamate/glycine (2 min; dots) and recorded from 4 different cultures in presence of DTT (1 mM) (n_cell = 43; A₁), DTT (1 mM) + Ifenprodil (2 μM) (n_cell = 21; B₁), L-Lactate (10 mM) + DTNB (200 μM) (n_cell = 62; C₁) or L-Lactate (10 mM) + Stiripentol (200 μM) (n_cell = 42; D₁). Only the reducing agent DTT alone potentiates the Ca²⁺ response evoked by the co-application of glutamate/glycine (A₁). (A₂,B₂,C₂ and D₂) Bar charts summarizing the significant potentiating effect of DTT (n_cult = 9; n_cells = 343; A₂) blocked by Ifenprodil (n_cult = 8; n_cells = 301; B₂) and the blockade of the L-Lactate-induced potentiation in presence of DTNB (n_cult = 8; n_cells = 407; C₂) or Stiripentol (n_cult = 9; n_cells = 298; D₂) on the Ca²⁺ signal triggered by co-application of glutamate/glycine. Results are presented as means ± SEM (*p < 0.05; paired t-test).