Table 3.
Summary of the rate of sustained plateau of Ca2+ signal (cell death process) induced by glutamate in different conditions.
| Glutamate/Glycine (1 mM/100 μM; 2 min) | % Ca2+ sustained plateau (Cell death process) | One-Way Anova |
|---|---|---|
| Control (ncult = 7; ncells = 263) |
51.4 ± 6.7 | |
| Ifenprodil (2 μM) (ncult = 6; ncells = 260) |
9.7 ± 3.4 | <0.005 |
| L-Lactate (2 mM) (ncult = 6; ncells = 338) |
42.6 ± 7.8 | n.s |
| L-Lactate (5 mM) (ncult = 6; ncells = 302) |
28.7 ± 4.9 | <0.05 |
| L-Lactate (10 mM) (ncult = 8; ncells = 282) |
22.7 ± 3.7 | <0.005 |
| Pyruvate (10 mM) (ncult = 6; ncells = 264) |
9.0 ± 3.7 | <0.005 |
| D-Lactate (10 mM) (ncult = 6; ncells = 246) |
38.5 ± 7.4 | n.s |
| L-Lactate (10 mM) + carbenoxolone (10 μM) (ncult = 5; ncells = 164) |
42.8 ± 3.5 | n.s |
| L-Lactate (10 mM) + glibenclamide (200 μM) (ncult = 4; ncells = 141) |
36.0 ± 4.0 | n.s |
| DTT (1 mM) (ncult = 6; ncells = 154) |
54.0 ± 7.5 | n.s |
Values are means ± SEM. Statistics data correspond to a Dunnett’s post hoc test following a one-way ANOVA (n.s: non significant, p > 0.05).