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. 2018 Sep 7;8:13423. doi: 10.1038/s41598-018-31536-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological recording setup and experimental protocols: (A) Photograph of the recording chamber and schematic drawing of its cross-sectional side view (lower panel). Hippocampal slice is about 650 μm away from the coil. (B) Microscopic image of the recording chamber from the top view. The image shows the location of the coil, hippocampal slice, and a reference electrode. S and R represent the stimulating and recording electrode, respectively. The recording electrode (R) is located in CA1. The stimulating electrodes S1 and S2 are located CA1/Subiculum and Schaffer collateral pathways. (C) Contact-mode magnetic stimulation (CMS) protocol for 120 min. QPS-patterned CMS is applied for 30 min after baseline recording. QPS-patterned CMS is composed of the pulse width of 5 ms, inter-stimulus interval (ISI) of 50 ms, inter-train interval (ITI) of 5 s, and a total number of the stimulus of 1440. (D) LTP protocol along with the timeline. High-frequency stimulation (HFS) pattern of 100 Hz for 1 s is applied twice with the interval of 30 s to the hippocampal slice.