Fig. 2.

Identification of tissue-specific gene modules during human fetal musculoskeletogenesis. a Hierarchical clustering of the top 5000 expressed genes across all five cell types. b Spearman correlation analysis of the total transcriptomes of the same five tissues. c WGCNA delineated 13 modules based on patterns of gene co-expression in each tissue. Each column represents a unique gene module. Relative gene expression levels are indicated using the color scale. d String network demonstrating validity and connectivity of selected tissue-specific genes from the chondrocyte (Yellow), osteoblast (Brown) and myoblast (Turquoise) gene modules. e Selected Gene Ontology terms enriched in the chondrocyte, osteoblast and myoblast modules. N = 3–4