Table 2.
Plasma HMGB1 and sputum HMGB1 levels in patients with bacterial community-acquired pneumonia, for different aetiologies.
| Aetiology | Plasma HMGB1 median(range), ng/mL | Number of patients | Sputum HMGB1 median (range), ng/mL | Number of patients |
|---|---|---|---|---|
| Streptococcus pneumoniae | 51 (6–320) | 63 | 118 (3–563)a | 19 |
| Haemophilus influenzae | 53 (20–153) | 16 | 5 (0–15) | 13 |
| Mycoplasma pneumoniae or Chlamydophila species | 69 (6–173) | 27 | 8 (0–77) | 8 |
| Staphylococcus aureus | 124 (60–201) | 3 | 12 (1–22) | 2 |
| Legionella pneumophila | 121 (67–175) | 2 | 0 |
aA statistically significant difference between S. pneumoniae-infected patients and patients with other aetiologies was shown by the Mann-Whitney U test, p = 0.002.