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. 2018 Sep 7;8:13429. doi: 10.1038/s41598-018-31759-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental setup for the concomitant recording of axonal trafficking and network maturation. Transport dynamics of dense core vesicles and mitochondria (upper green box) were recorded in the distal part of axonal channels and kymographs were analyzed using the indicated kinetic parameters. Synaptic formation (left blue box) was analyzed by quantifying the number of adjacent spots of synaptophysin (presynaptic) and PSD95 (postsynaptic) per 100 μm. Glutamatergic transmission (right blue box) was assessed by quantifying the number of iGluSnFR spots per mm² after cortical stimulation (right). Network activity and synchrony (lower orange box) was assessed using calcium imaging of GCaMP6f in striatal neurons.