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. 2018 Sep 7;8:13477. doi: 10.1038/s41598-018-31540-0

Figure 3.

Figure 3

Histopathologic and immunohistochemical findings associated with antigens of canine distemper virus in puppies. There is degeneration, absence, and chromatolysis of Purkinje cells of the cerebellum (A). Observe positive immunoreactivity to CDV antigens within all layers of the cerebellar cortex (B), within necrotic Purkinje cells (C), neurons of the white matter of the cerebrum (D), and within astrocytes of the white matter of the cerebellum (E). There is positive immunoreactivity to CDV antigens within pulmonary macrophages, epithelial cells of mixed glands, and epithelial cells of bronchiole (F) and the bronchiolar epithelium (G) of the lungs of a Yorkshire terrier puppy (#3) with interstitial pneumonia. Observe positive immunolabelling of CDV antigens within syncytia, macrophages, and alveolar epithelial cells (H) of a Labrador retriever puppy (#2) with purulent bronchopneumonia. (A) Haematoxylin and Eosin stain; (B–H) immunoperoxidase. Bar, (A,C,D,G,H) 50 µm; (B) and (F) 200 µm.