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. 2018 Sep 7;8:13477. doi: 10.1038/s41598-018-31540-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathologic and immunohistochemical findings associated with CAdV-1 infection in puppy # 15. Eye, there is marked oedema of the stroma (St) and dislocation (arrow) of the Descemet’s membrane (DM) of the cornea (A). Eye, observe ballooning degeneration of the epithelial cells of the corneal anterior (CEp) with disruption (arrow) of the basement membrane (B) and at Descemet’s membrane (DM) of the cornea, and without any inflammatory reaction at the corneal endothelium (B,C). Conjunctiva, observe focus of moderate lymphoplasmacytic inflammatory cells that are adjacent to degenerative and necrotic epithelial cells of the lacrimal gland (D). There is the positive immunoreactivity to CAdV-1 antigens at the degenerated and necrotic epithelial cells of the lacrimal glands at the conjunctiva (E), the degenerated epithelial cells (arrows) of the cornea (F,G), and bile duct epithelial cells of the liver (F). (A–D) Haematoxylin and Eosin stain; (E–H) immunoperoxidase. Bar, (A) 200 µm, (B–G) 50 µm.