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. 2018 Sep 7;8:13447. doi: 10.1038/s41598-018-29859-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Broad control of GRF transcrition factors by miRNA miR396. (a) Phylogenetic tree using the full-length amino acid sequences of the Arabidopsis GRFs constructed by the neighbor joining method. Bootstrap support greater than 50% are indicated on nodes. (b) Scheme representing the exon-intron structure, the localization of the WRC and QLQ protein domains and the miR396-binding site. (c) Scheme representing a typical GRF gene and a detailed view of the interaction of Arabidopsis GRFs with miR396. (d) Distribution of GRFs in representative plants species and the occurrence of miR396 regulation among them.