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. 2018 Sep 7;8:13434. doi: 10.1038/s41598-018-31829-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biotin does not diffuse into the stratum corneum of skin equivalents with primary and SVTERT KC. Biotin was added to the surface of fully developed human skin equivalents (HSE). In all HSE biotin could not penetrate the stratum corneum into the deeper layers within 60 min. Scale bar = 120 µm.