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. 2018 Sep 7;8:13451. doi: 10.1038/s41598-018-31603-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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E-cadherin plays an indispensable role in postnatal exocrine tissue architecture. (A,C,E,G) Whole-mount images of the pancreas (Pan), spleen (Sp), stomach (St) and duodenum (Du) of control and Cdh1^ΔPan/ΔPan animals at P0 (A,C) and P4 (E,G). Higher magnification views of the dorsal (DP, A’,C’,E’,G’) and ventral (VP, A”,C”,E”,G”) pancreas are shown. White scale bars = 250 μm. Red contour indicates edge of duodenum. White arrowheads indicate cystic exocrine structures. (B,D,F,H) Immunofluorescence analysis of acinar (amylase, green), ductal (DBA, white), and endocrine (Chromogranin A, red) compartments of control (B,F) and Cdh1^ΔPan/ΔPan (C,H) mice at both P0 and P4. Yellow scale bars = 100 μm. (I,J) Whole-mount immunofluorescence images showing the distribution of ductal (Muc1, red) and exocrine (Epcam, green) compartments in the control (I) or Cdh1^ΔPan/ΔPan (J) pancreas at P4.