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. 2018 Sep 7;8:13451. doi: 10.1038/s41598-018-31603-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impairment of adherens junctions and disrupted exocrine tissue integrity in Cdh1^ΔPan/ΔPan pancreata. (A–D) Immunofluorescence analysis of Epcam (red) and DAPI (white) in control (A,C) and Cdh1^ΔPan/ΔPan (B,D) pancreata at P0 and P4. Higher magnification views of yellow inset boxes are shown to the right in (A’,B’,C’,D’). (E–H) Transmission electron micrographs from control (E,G) and Cdh1^ΔPan/ΔPan (F,H) pancreata at P0 and P4. Higher magnification views of red inset boxes are shown to the right in (E’–H’). White arrows point to tight junctions (TJs) and adherens junctions (AJs) as indicated. (I–L) Immunofluorescence analysis of Epcam (red), Laminin (green), and Osteopontin (white) in the pancreas of control (I,K) or Cdh1^ΔPan/ΔPan (J,L) mice at P0 and P4. White asterisks indicate dilated/cystic exocrine structures. White scale bars = 100 μm. Red scale bars = 2 μm.