Fig. 2.

Leiomyoma risk variants intersecting with regulatory regions and their candidate target genes. Two loci on chromosomes 6 (upper panel) and 13 (lower panel) are shown as examples. Acetylation of lysine residue K27 of histone H3 (H3K27ac) and open chromatin (DHS, DNase Hypersensitivity Sites) in the uterus samples are shown as tick marks at the top. At chromosome 6, the lead variant rs58415480 is shown along with the only other variant in the same LD class (r² > 0.8), rs71575922. At chromosome 13, rs117245733 is in an LD class by itself, i.e., does not have strongly correlated markers. Candidate target genes were identified by the analysis of available chromatin interaction maps, shown on the figure as orange arcs. The shaded regions represent regions found in contact with the regulatory variants