Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 7;8:13438. doi: 10.1038/s41598-018-31680-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Structure of PICK1 with compound 1o. (A) Structure of compound 1o. (B) Specific binding of 1o to the PICK1 PDZ domain showing a 3-pronged pharmacophore entering pockets S₀ (“R3”), S₋₁ (“R1”), and S₋₂ (“R2”). (C) Overall conformation of the PICK1 dimer and location of compound 1o binding (yellow and blue) in the peptide groove of each monomer (green and magenta). (D) Superposition of PICK1 alpha-carbons with the 3HPK PICK1 structure highlighting difference between peptide (SVKI; Red) and compound 1o (green) (E), Stacking between R1 aromatic group of compound 1o and Phe53 including the subpocket (F), Surface representation demonstrating interaction between fluorophenyl (R2) and Ala87, Lys83.